About Us
David H. Crean, Ph.D., MBA
Managing Partner
Cardiff Advisory
The Firm
Cardiff Advisory is a boutique strategic, corporate finance, and & acquisitions & advisory firm, specializing primarily in the healthcare and life sciences sectors. The firm core high touch offering combines:
Investment Banking Services:
Focused on founder-led and lower-middle-market companies, these services include sell-side and buy-side M&A mandates, licensing, divestitures, strategic partnerships, and valuation services. Cardiff Advisory runs disciplined process management from valuation and due diligence through negotiation and closing.
Strategic Mentoring and Advisory:
The Cardiff Advisory team provides Board- level support, C-suite and founder guidance, integrating deep scientific/commercial diligence with rigorous financial foresight. This advisory work is designed to help companies identify sustainable value, achieve science-to-market acceleration, build financial resilience, and secure optimal strategic fit, often acting as a mentor to synchronize scientific promise with market timing and investor expectations.
Cardiff Advisory is your strategic partner that combines specialized investment banking execution with expert mentoring to create and maximize value for emerging and established companies in complex, high-growth industries like healthcare and life sciences.
The Firm
Cardiff Advisory is a boutique strategic, corporate finance, and & acquisitions & advisory firm, specializing primarily in the healthcare and life sciences sectors. The firm core high touch offering combines:
Investment Banking Services:
Focused on founder-led and lower-middle-market companies, these services include sell-side and buy-side M&A mandates, licensing, divestitures, strategic partnerships, and valuation services. Cardiff Advisory runs disciplined process management from valuation and due diligence through negotiation and closing.
Strategic Mentoring and Advisory:
The Cardiff Advisory team provides Board- level support, C-suite and founder guidance, integrating deep scientific/commercial diligence with rigorous financial foresight. This advisory work is designed to help companies identify sustainable value, achieve science-to-market acceleration, build financial resilience, and secure optimal strategic fit, often acting as a mentor to synchronize scientific promise with market timing and investor expectations.
Cardiff Advisory is your strategic partner that combines specialized investment banking execution with expert mentoring to create and maximize value for emerging and established companies in complex, high-growth industries like healthcare and life sciences.
Mission & Vision
Mission
The firm’s mission is to create and maximize sustainable value for companies in the healthcare and life sciences sectors by coupling deep scientific rigor with disciplined strategic financial foresight and expert M&A execution.
Vision
Its vision is to be the leading strategic partner for founders and entrepreneurs as they navigate their journeys enabling science-to-market acceleration, capital investment, and successful financial outcomes. The firm’s decision-making is guided by the principle that every transaction must unlock a state for the future entity that is fundamentally and quantifiably superior to the sum of its previous parts. It must also achieve the objectives of its owners and stakeholders.
Why was the Firm Started?
Dr. David H. Crean founded Cardiff Advisory in 2020 to fill a specific gap he identified in the strategic advisory and transaction services available to companies in the life sciences and healthcare sectors.His decision was rooted in the conclusion that founders and entrepreneurs were often not receiving the highest caliber of counsel necessary for critical transactions.
Dr. Crean, leveraging over 30 years of experience across biopharma, investment banking, private equity, and venture capital, determined that the existing advisory landscape often fell short in two key areas:
Lack of Deep Domain Expertise: Founders were not consistently getting sound strategic advisory from advisors with genuine deep domain expertise in life sciences and significant deal-making experience. Transactions in biotech and healthcare require a nuanced understanding of scientific rigor, regulatory pathways, and clinical milestones that generalist investment bankers or corporate advisors and consultants often lack.
Junior-Driven Transaction Management: Advice from large “bulge bracket” investment banks often involved large teams, but the day-to-day transaction process was frequently driven by junior analysts rather than by highly experienced Managing Directors (MDs). This structure could lead to less strategic, hands-on guidance for founder-led and lower-middle-market companies.
Cardiff Advisory’s Solution
Cardiff Advisory was created to offer a specialized alternative:
MD-Led Focus: The firm provides a boutique, high-touch model where transaction management and strategic advice are led by seasoned professionals like Dr. Crean, ensuring founders benefit directly from their cross-functional remit and deep experience.
Integrated Scientific and Financial Acumen: The core practice couples deep biological assessment with disciplined financial foresight, which is critical for converting science-driven opportunity into measurable enterprise value in life sciences. This approach ensures that scientific promise, market timing, and investor expectations are tightly synchronized for the client.
The firm functions as a strategic partner that combines specialized investment banking execution with expert C-suite/founder-level mentoring focused on the complex, high-growth environment of life sciences and healthcare.
Mission & Vision
Mission
The firm’s mission is to create and maximize sustainable value for companies in the healthcare and life sciences sectors by coupling deep scientific rigor with disciplined strategic financial foresight and expert M&A execution.
Vision
Its vision is to be the leading strategic partner for founders and entrepreneurs as they navigate their journeys enabling science-to-market acceleration, capital investment, and successful financial outcomes. The firm’s decision-making is guided by the principle that every transaction must unlock a state for the future entity that is fundamentally and quantifiably superior to the sum of its previous parts. It must also achieve the objectives of its owners and stakeholders.
Why was the Firm Started?
Dr. David H. Crean founded Cardiff Advisory in 2020 to fill a specific gap he identified in the strategic advisory and transaction services available to companies in the life sciences and healthcare sectors.His decision was rooted in the conclusion that founders and entrepreneurs were often not receiving the highest caliber of counsel necessary for critical transactions.
Dr. Crean, leveraging over 30 years of experience across biopharma, investment banking, private equity, and venture capital, determined that the existing advisory landscape often fell short in two key areas:
Lack of Deep Domain Expertise: Founders were not consistently getting sound strategic advisory from advisors with genuine deep domain expertise in life sciences and significant deal-making experience. Transactions in biotech and healthcare require a nuanced understanding of scientific rigor, regulatory pathways, and clinical milestones that generalist investment bankers or corporate advisors and consultants often lack.
Junior-Driven Transaction Management: Advice from large “bulge bracket” investment banks often involved large teams, but the day-to-day transaction process was frequently driven by junior analysts rather than by highly experienced Managing Directors (MDs). This structure could lead to less strategic, hands-on guidance for founder-led and lower-middle-market companies.
Cardiff Advisory’s Solution
Cardiff Advisory was created to offer a specialized alternative:
MD-Led Focus: The firm provides a boutique, high-touch model where transaction management and strategic advice are led by seasoned professionals like Dr. Crean, ensuring founders benefit directly from their cross-functional remit and deep experience.
Integrated Scientific and Financial Acumen: The core practice couples deep biological assessment with disciplined financial foresight, which is critical for converting science-driven opportunity into measurable enterprise value in life sciences. This approach ensures that scientific promise, market timing, and investor expectations are tightly synchronized for the client.
The firm functions as a strategic partner that combines specialized investment banking execution with expert C-suite/founder-level mentoring focused on the complex, high-growth environment of life sciences and healthcare.
Our Process
Preparation and Positioning
Establish objectives
- Target potential buyers / sellers / investors
Develop marketing strategies
- Work closely with your financial and legal advisors throughout
Engage and Qualify
Distribute Information Memorandum
Facilitate initial due diligence
Meet with qualified buyer, sellers or investors
Solicit and receive offers
Select partners
Negotiate and Close
Negotiate price
Establish milestones
Negotiate purchase, partnership or financing
Facilitate due diligence
Close deal and facilitate integration
Process Duration
Typical process duration is 6-9 months
Our Process
Preparation and Positioning
Establish objectives
- Target potential buyers / sellers / investors
Develop marketing strategies
- Work closely with your financial and legal advisors throughout
Engage and Qualify
Distribute Information Memorandum
Facilitate initial due diligence
Meet with qualified buyer, sellers or investors
Solicit and receive offers
Select partners
Negotiate and Close
Negotiate price
Establish milestones
Negotiate purchase, partnership or financing
Facilitate due diligence
Close deal and facilitate integration
Process Duration
Typical process duration is 6-9 months
Cardiff Careers
Investment Banking
Managing Director
• M&A and Strategic Advisory
• Full Time
• On Site / Remote
• San Diego Location
• Full Benefits
• 2026 Start Date
Investment Banking
Assistant
• Part time – up to 10 hours per week
• Remote
• Research and report preparation
• Client communications
• Manage emails, appointments, & calls
• Administrative tasks
• Social media accounts
• 2026 Start Date
Cardiff Careers
Investment Banking
Managing Director
• M&A and Strategic Advisory
• Full Time
• On Site / Remote
• San Diego Location
• Full Benefits
• 2026 Start Date
Investment Banking
Assistant
• Part time – up to 10 hours per week
• Remote
• Research and report preparation
• Client communications
• Manage emails, appointments, & calls
• Administrative tasks
• Social media accounts
• 2026 Start Date
Connect
Ready to explore M&A or partnership options?
Connect with Cardiff Advisory to assess your company’s market position and identify the right strategic alternatives.
Connect
Ready to explore M&A or partnership options?
Connect with Cardiff Advisory to assess your company’s market position and identify the right strategic alternatives.